ABSTRACT
OBJECTIVE The impact of A. calamus extract and C. Pereira extract on heart hypertrophy caused by isoproterenol. A. calamus extract & C. Pereira extract on heart hypertrophy by thyroxine. MATERIAL AND METHOD a. Animal House Pharmacy School (Wistar rats), measuring 180-250 grammes, BIT Meerut (UP). One week before the research began, they were kept separately in polypropylene cages in a quarantine room. b. C. Pareira and A. calamus rhizomes from the School of Pharmacy at the Medicinal Garden, BIT, Merrut, UP, India. METHODS Influence of C. Pareria Extract on Isoproterenol- induced cardiac hypertrophy in rats. Influence of A. Calamus Extract on Isoproterenol- induced cardiac hypertrophy in rats. Influence of C. Pareria Extract on Thyroxine- induced cardiac hypertrophy in rats Influence of A Calamus Extract on Thyroxine- induced cardiac hypertrophy in rats. RESULTS In comparison with control and C. Pareira and A. Calamus as well as amlodipine treated groups in the ISO treatment community, no major alteration was identified in the MAP. There was no MAP change in T4 compared with controls and groups C. pareira and amlodipine treated with T4. Significantly increased T4 (P < O.O1) HR administration against power.No significant change in HR was detected in C. Pareira and A. calamus. CONCULSION Cissampelos pareira and Acorn calamus effect in cardiac hypertrophy induced by isoproterenol Isoproterenol chronic administration (5 mg/lcg/day, 30 days), cardiac hypertrophy, cardiac weight ratio, angiotensin II, tumour factor necrosis, calcineurin, oxide/reactive nitrients, NaV K'